Selected Publications
Francis AC, Marin M, Prellberg MJ, Palermino-Rowland K, Melikyan GB. HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages. Viruses. 2020 Oct 30;12(11):1234. doi: 10.3390/v12111234. PMID: 33143125; PMCID: PMC7693591.
Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Jul 14;11(1):3505. doi: 10.1038/s41467-020-17256-8. Erratum in: Nat Commun. 2020 Nov 26;11(1):6165. PMID: 32665593; PMCID: PMC7360574.
Francis AC, Melikyan GB. Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009. PMID: 29649444; PMCID: PMC5901770.
Sood C, Francis AC, Desai TM, Melikyan GB. An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions. J Biol Chem. 2017 Dec 8;292(49):20196-20207. doi: 10.1074/jbc.M117.818088. Epub 2017 Oct 18. PMID: 29046351; PMCID: PMC5724006.
Francis AC, Marin M, Shi J, Aiken C, Melikyan GB. Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells. PLoS Pathog. 2016 Jun 20;12(6):e1005709. doi: 10.1371/journal.ppat.1005709. PMID: 27322072; PMCID: PMC4913920.
Francis AC, Di Primio C, Quercioli V, Valentini P, Boll A, Girelli G, Demichelis F, Arosio D, Cereseto A. Second generation imaging of nuclear/cytoplasmic HIV-1 complexes. AIDS Res Hum Retroviruses. 2014 Jul;30(7):717-26. doi: 10.1089/AID.2013.0277. Epub 2014 Jun 6. PMID: 24798748; PMCID: PMC4077004.
Review articles and book chapters
Francis AC, Melikyan GB. Live-Cell Imaging of Early Steps of Single HIV-1 Infection. Viruses. 2018 May 19;10(5):275. doi: 10.3390/v10050275. PMID: 29783762; PMCID: PMC5977268.
Francis AC, Di Primio C, Allouch A, Cereseto A. Role of phosphorylation in the nuclear biology of HIV-1. Curr Med Chem. 2011;18(19):2904-12. doi: 10.2174/092986711796150478. PMID: 21651489.